1st EVIta Symposium 2019 - Program

6-8 November 2019

Palermo, Italy

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Wednesday, 6 November 2019


Welcoming Day

18:00

Registration to the 1st EVIta Symposium

18:30

Opening remarks

Institutional welcome

Welcome by the Local Organizing Committee

19:00-19:30

Opening Lecture: Dolores Di Vizio - CEDARS-Sinai Mediacal Center, USA

“Cancer-Derived Extracellular vesicles and Large Oncosomes: From Biology to Biomarkers”

Chairs:

Riccardo Alessandro - University of Palermo, Italy

Antonella Bongiovanni IRIB, CNR, Italy

19:30

Welcome Cocktail

21:30

Jazz Time


Thursday, 7 November 2019


1st Day 

08:00-8:45

Registration to the 1st EVIta Symposium

08:45-9:00

Welcome Remarks

Benedetta Bussolati, EVIta President

University of Turin, Italy

09:00-10:15

Session I - EVs as Therapeutics (I)    

Chairs:

Lorenza Lazzari - Policlinico of Milan, Italy

Lucio Barile - Cardiocentro Ticino Foundation, Switzerland

 

Roberta Tasso, University of Genoa

“Mesenchymal stromal cell-derived extracellular vesicles (EVs) as mediators of antiinflammatory effects: endorsement of macrophage polarization”.

Elia Bari, University of Pavia

“MSC extracellular vesicles for treatment of alpha-1-antitrypsin deficiency pulmonary diseases”.

Papadimitriou Elli, University of Turin

“Urinary extracellular vesicles carrying klotho improve the recovery of renal function in acute tubular injury model”.

Giorgia Adamo, IRIB, CNR, Palermo

VES4US, a Horizon 2020-Future and Emerging Technology project: Selection and characterization of natural source derived extracellular vesicles (EVs).

Federica Collino, University of Padua

“Extracellular vesicles from adipose mesenchymal stromal cells promote cardio-renal protection in DOCA-salt hypertensive model”.

10:15-10:45

Morning Lecture: Kenneth Witwer, ISEV Board Member

Johns Hopkins University, USA

“Direct from the source: can we separate tissue EVs to inform the biomarker search?”

Chairs:

Benedetta Bussolati - University of Turin, Italy

Dolores Di Vizio- CEDARS-Sinai Mediacal Center, USA

10:45-11:00

Coffee break

11:00-13:15

Session II – EVs as Biomarkers          

Chairs:

Massimiliano Bonafè - University of Bologna, Italy

Italia Di Liegro - University of Palermo, Italy

 

Chiara Castellani, University of Padua

“Extracellular vesicles surface protein profile as biomarkers to characterize allograft rejection in heart transplanted patients”.

Celeste Caruso Bavisotto, University of Palermo

“Exosomal HSP60 levels and related miRNAs in brain tumors”.

Silvia Picciolini, Don Gnocchi Foundation, Milan

“Biophotonics-based biosensor for the detection of circulating extracellular vesicles as biomarkers in personalized neurorehabilitation”.

Emanuela Mensà, Marche Polytechnic University, Ancona

MicroRNA signatures loaded on small vesicles spread some features of senescent phenotype from senescent to younger endothelial cells”.

Vito D'Agostino, CIBIO - University of Trento

“Quantitative assessment of RNA targets on NBI-isolated extracellular vesicles from the blood of metastatic colorectal cancer patients”.

Laura Cantone, University of Milan

“Maternal-placental messaging through extracellular vesicles is influenced by particulate air pollution exposure”

Burrello Jacopo, University of Turin

“Circulating extracellular vesicles as biomarkers in patients after ST-segment elevation myocardial infarction”.

Federica Anastasi, Scuola Normale Superiore, Pisa

“Microproteomics workflow for exosome biomarker discovery: enabling single mouse analysis on longitudinal models”.

Daniele D'Arrigo, Ente Ospedaliero Cantonale, Bellizona

Characterization of the whole profile of extracellular vesicles isolated from synovial fluid from different load-bearing joints”.

13:15-14:30

Light Lunch and Poster Session:

“EVs as Therapeutics” and “EVs as Biomarkers”

14:30-14:50

Biotech Sponsored Session I

Chairs:

Marina Cretich - Scitec (ICRM), CNR, Italy

Francesco Valle - University of Bologna, Italy

Alfatest

Nanoview

Beckman Coulter

15:00-15:30

Afternoon Lecture: Selim Ünlü

University of Boston, USA

“High-throughput, high-resolution interferometric light microscopy of biological nanoparticles”.

Chair:

Marcella Chiari - Scitec (ICRM) , CNR, Italy

15:30-18:00

Session III – EV Biology and Tools   

Chairs:

Maria Felice Brizzi - University of Turin, Italy

Marco Tripodi - University of Rome, Italy

 

Felice Maria Accattatis, DISFEB - University of Milan

“Size-dependent Extracellular Vesicles lipid composition. In vitro studies from a lymph-node metastatic melanoma cell line”.

Italia di Liegro, Bi.N.D., University of Palermo

“Potential roles of extracellular vesicles in brain cell-to-cell communication”.

Mauro Manno, IBF, CNR, Palermo

 “VES4US, a Horizon 2020 Future and Emerging Technology project: Biophysical experimental tools for EVs structural characterization”.

Paolo Bergese, DMMT, University of Brescia

“Projecting extracellular vesicles in two dimensions”.

Marina Cretich, Scitec (ICRM) , CNR, Milan

Membrane sensing peptide microarrays for Extracellular Vesicles”.

Serena Maggio, University of Urbino

“The Possible role of Extracellular Vesicles in Neuromuscular Junction pre-patterning”.

Marta Brambilla, Centro Cardiologico Monzino, IRCCS Foundation, Milan

“Differential contribution of microvesicles derived from platelets and monocytes of coronary artery disease patients to endothelial dysfunction”.

Cecilia Battistelli, Sapienza, University of Rome

“RNA binding proteins (RBPs) control sequence-specific miRNAs sorting in extracellular vesicles (EVs)”

Christopher Stanly, IBBR, CNR, Naples

Preparative and Analytical ultracentrifugation of EVs”.

Marco Brucale, ISMN, CNR, Rome

Nanomechanics of individual extracellular vesicles”.

20:00

Gala Dinner at Massimo Theatre Bistro


Friday, 8 November 2019


2nd Day

08:15-09:45

Session IV - EVs as Therapeutics (II)

Chairs:

Anna Berardi - Santo Spirito Hospital of Pescara, Italy

Simona Fontana - University of Palermo, Italy

 

Chiara Gai, University of Turin

“Improved loading of plasma-derived extracellular vesicles to encapsulate antitumour miRNAs”.

Roberta Angioni, University of Padua

“CD73+ extracellular vesicles inhibit angiogenesis through adenosine A2B receptor signaling”.

Valentina Di Felice, University of Palermo     

“Physiactisome: a new drug from engineered muscle cells that mimics physical exercise”.

Mario Barilani, IRCCS Foundation, Milan

“Pluripotent EV as carriers of regenerative prompts in aged cells”

Carolina Balbi, Cardiocentro Ticino Foundation, Lugano

“Cardiac progenitor cell exosome-associated periostin triggers reentry of cardiomyocytes into cell cycle”.

Cansu Gorgun, University of Genoa

“Mesenchymal stromal cell secretory activity: the role of extracellular vesicles in angiogenesis”.

09:45-10:15

Morning Lecture: Peter Nejsum        

University of Aarhus, Denmark

“A new level of complexity in host-parasite interaction – extracellular vesicles”.

Chairs:

Paolo Bergese - University of Brescia, Italy

Annalisa Radeghieri - University of Brescia, Italy

10:15-10:30

Coffee break

10:30-11:00

Biotech Sponsored Session II

Chairs:

Mauro Manno - IBF, CNR, Italy

Stefania Bruno - University of Turin, Italy       

Izon

NanoFCM

Particle Metrix GmbH

11:00-13:00

Session V - EVs in pathogenesis of diseases (I)                

Chairs:

Roberta Tasso - University of Genoa, Italy

Claudia Verderio- IN, CNR, Italy

 

Goffredo Arena, McGill University, Montreal

“Cancer EVs convey metastatic traits through horizontal gene transfer”

Vanessa Biemmi, Cardiocentro Ticino Foundation, Lugano

Cardiac dysfunction after myocardial infarction: role of pro-inflammatory extracellular vesicles”.

Manuela Basso, University of Trento

“Intercellular miscommunication in the brain and periphery: characterization of extracellular vesicle in Amyotrophic Lateral Sclerosis”.

Stefania Raimondo, University of Palermo

“Role of multiple myeloma exosomal miRNAs in the inhibition of osteoblast differentiation”.

Alessia Brossa, University of Turin

“Extracellular vesicles from liver stem cells inhibit renal cancer stem cell-derived tumor growth in vitro and in vivo”.

Pina Fusco, University of Padua

“Microscale technologies to decode the role of hypoxia-derived exosomes in determining Neuroblastoma dissemination and aggressiveness”.

Chiara Ciardiello, IRCCS, Istituto Nazionale Tumori, G. Pascale Foundation, Naples

“Large Oncosomes detection in diverse solid tumors showed a priming effect on tumor engraftment in vivo”.

Valentina Zappulli, BCA Department, University of Padua

“Glioma-derived miRNA-containing extracellular vesicles induce angiogenesis by reprogramming brain endothelial cells”.

13:00-14:15

Light Lunch and Poster Session:

“EV Biology and Tools” and “EVs in pathogenesis of diseases”

14:15-16:00

Session VI - EVs in pathogenesis of diseases (II)            

Chairs:

Goffredo Arena - McGill University, Canada

Marina Camera- University of Milan, Italy

 

Domenica Giannandrea, University of Milan

“Targeting extracellular vesicles in multiple myeloma: a new role for the Notch pathway”.

Andrea Caccioppo, DMS, University of Turin

“Role of exosomes in Acute Coronary Syndrome”.

Alessandra De Feo, Sapienza, University of Rome

“Exosomes enriched for miR-199a-3p reverse tumor malignancy in Ewing sarcoma cells”

Verderio Claudia, IN, CNR, Pisa

“Glial microvesicles in motion at the neuron surface: implication in Alzheimer’s disease”.

Daisy Sproviero, IRCCS Mondino Foundation, Padua

“Distinct microRNA signature in exosomes of neurodegenerative diseases”.

Donatella Lucchetti, Cattolica, University of Rome

“CD147 promotes cell exosome release during colon cancer stem cells differentiation and triggers cellular changes in recipient cells”.

Leggio Loredana, BIOMETEC, University of Catania

Ultrastructural and molecular characterization of astrocyte-derived extracellular vesicles from nigrostriatal brain regions: implications for dopaminergic neuroprotection”.

16:00-16:30

Afternoon Lecture: Stefano Pluchino

University of Cambridge, UK

“Signaling Properties of Stem Cells and their Cargo Vesicles”.

Chairs:

Francesco Cappello - University of Palermo, Italy

Valentina Di Felice- University of Palermo, Italy

16:30-17:00

Closing Remarks and Awards

Vincenza Dolo, EVIta Vice-President

University of L’Aquila, Italy

18:00-19:30

EVIta Annual Assembly with closing cocktail at Ridotto dello Spasimo-Blue Brass (Chiesa di Santa Maria dello Spasimo)